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The crash happened just before 5:45 p.m. on Wednesday, Nov. 27, in Brentwood.
Suffolk County Police said a 24-year-old Brentwood woman was driving a 2012 Acura TL and turning left onto eastbound Suffolk Avenue from Eisenhower Avenue when she struck a pedestrian in the roadway.
The victim, who has not yet been identified, was pronounced dead at the scene by a physician assistant from the Office of the Suffolk County Medical Examiner, police said.
The driver of the Acura was not injured in the crash.
The vehicle was impounded for a safety check.
Anyone with information is asked to contact Suffolk County police at 631-854-8352.
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